Na 2-Methylamino-5-Nitro-2'-Fluorobenzophenone ke Phallo e Latelang Lipatlisisong tsa Lithethefatsi?

Na u kile ua ipotsa hore na ke metsoako efe e mecha e bōpang bokamoso ba meriana? K'hemik'hale e 'ngoe e fumanang tlhokomelo lipatlisisong tsa meriana ke 2-Methylamino-5-Nitro-2'-Fluorobenzophenone. Empa ke eng e etsang hore motsoako ona o thahaselle hakaale, ’me na e ka ’na ea e-ba katleho e latelang ea ntlafatso ea lithethefatsi?

2-Methylamino-5-Nitro-2'-Fluorobenzophenone ke Eng?

2-Methylamino-5-Nitro-2'-Fluorobenzophenone ke motsoako o khethehileng oa lik'hemik'hale o sebelisoang haholo-holo lipatlisisong tsa meriana. E sebetsa e le setsi sa bohlokoa ho kopanngoeng ha metsoako e sebetsang ea meriana (APIs). Sebopeho sa eona se ikhethang, se kenyelletsang lihlopha tsa methylamino, nitro, le fluorobenzophenone, se fana ka thepa e tšepisang eo bafuputsi ba labalabelang ho e hlahloba bakeng sa litlhare tse ncha tsa lithethefatsi.

Ke Hobane'ng ha 2-Methylamino-5-Nitro-2'-Fluorobenzophenone e le Bohlokoa Lipatlisisong tsa Lithethefatsi?

Ho nts'etsopele ea lithethefatsi, ho fumana metsoako e ka lebisang meriana e sireletsehileng, e sebetsang haholoanyane ke senotlolo. 2-Methylamino-5-Nitro-2'-Fluorobenzophenone e thahasella hobane e thusa ho theha limolek'hule tse nang le ts'ebetso e ntlafetseng ea likokoana-hloko le botsitso. Mohlala, liathomo tsa fluorine ka har'a limolek'hule li atisa ho eketsa botsitso ba metabolism le ho ntlafatsa bokhoni ba lithethefatsi ho sebelisana le sepheo sa bona, ho etsa hore phekolo e atlehe haholoanyane.

Ho latela phuputso e phatlalalitsoeng ho Journal of Medicinal Chemistry (2022), metsoako e kenyelletsang meaho ea fluorobenzophenone e bonts'itse ho fihla ho 30% bioavailability e betere ha e bapisoa le limolek'hule tse tšoanang ntle le fluorine. Sena se fana ka maikutlo a hore metsoako e kang 2-Methylamino-5-Nitro-2'-Fluorobenzophenone e ka bapala karolo ea ho hlahisa lithethefatsi tse molemo.

Lisebelisoa tsa 2-Methylamino-5-Nitro-2'-Fluorobenzophenone ho Pharmaceutical R&D

Motsoako ona o sebelisoa haholo-holo e le mohaho oa mohaho nakong ea motsoako oa limolek'hule tse rarahaneng. E bohlokoa haholo ho theheng lithethefatsi bakeng sa libaka tse kang oncology, kalafo ea antiviral, le kalafo ea ho ruruha. Ho feto-fetoha ha eona ho etsa hore e be sesebelisoa sa bohlokoa bakeng sa litsebi tsa lik'hemik'hale tsa meriana tse sebetsanang le mekhoa ea phekolo e tsoetseng pele.

Bafuputsi ba ananela kamoo 2-Methylamino-5-Nitro-2′-Fluorobenzophenone e thusang ho qaptjoa ha limolek'hule tse khethollang le tse matla haholoanyane. Sena se ka lebisa ho lithethefatsi tse nang le litla-morao tse fokolang le liphello tse molemo tsa mokuli.

Mathata a ka Sehloohong a ho sebetsa le 2-Methylamino-5-Nitro-2′-Fluorobenzophenone

Ha e ntse e tšepisa, ho sebetsa le 2-Methylamino-5-Nitro-2'-Fluorobenzophenone ho hloka ho sebetsana ka hloko le maemo a nepahetseng a ho kopanya. Ho netefatsa bohloeki le botsitso ho bohlokoa bakeng sa nts'etsopele ea lithethefatsi e tšepahalang. Patlisiso e ntseng e tsoela pele e tsepamisitse maikutlo ho ntlafatseng lits'ebetso tsena ho etsa hore tlhahiso ea lithethefatsi e atlehe haholoanyane.

Hobaneng ha Jingye Pharmaceutical e le Molekane ea Tšeptjoang ho 2-Methylamino-5-Nitro-2′-Fluorobenzophenone Supply

Ho Jingye Pharmaceutical, re sebetsa ka thata ho etsa lipatlisiso, nts'etsopele le tlhahiso ea li-intermediate tsa boleng bo holimo tsa meriana, ho kenyeletsoa 2-Methylamino-5-Nitro-2'-Fluorobenzophenone. Ka lilemo tse fetang leshome tsa boiphihlelo, k'hamphani ea rona e ikemiselitse ho:

1. Taolo e tiileng ea boleng ho netefatsa bohloeki le botsitso ba sehlahisoa

2. Mehaho e tsoetseng pele ea tlhahiso e hlomelloang bakeng sa ho qaptjoa ka mokhoa o sireletsehileng le o sebetsang hantle

3. Sehlopha sa profeshenale sa R&D se inehetseng ho boqapi le tšehetso ea bareki

4. Tsamaiso ea phepelo e tšepahalang ho netefatsa phano e nakong

Boinehelo ba rona bo re etsa mofani oa thepa ea ratoang bakeng sa lik'hamphani tsa meriana tse batlang li-intermediate tsa boemo bo holimo tse finyellang litekanyetso tse thata tsa indasteri.

Is 2-Methylamino-5-Nitro-2'-Fluorobenzophenonentho e latelang e kholo lipatlisisong tsa lithethefatsi? Bopaki bo supa bohlokoa ba eona bo ntseng bo hola ho R&D ea meriana le synthesis. Mehaho ea eona e ikhethang le ho feto-fetoha ha maemo ho etsa hore e be karolo ea bohlokoa ho theheng meriana e betere bakeng sa bokamoso. Ha lipatlisiso li ntse li tsoela pele, motsoako ona o ka fetoha motheo oa ho hlahisa lithethefatsi tsa moloko o latelang.